Dr. John Southern
Assistant Professor, Chemistry
Publications and Further Research Outputs
Peer-Reviewed Publications
McDonnell, C.M. and Ghanim, M. and Mike Southern, J. and Kelly, V.P. and Connon, S.J., De-novo designed β-lysine derivatives can both augment and diminish the proliferation rates of E. coli through the action of Elongation Factor P, Bioorganic and Medicinal Chemistry Letters, 59, (128545), 2022
Introduction to Aromatic Chemistry in, editor(s)Chris Rostron, Jill Barber , Pharmaceutical Chemistry, Second Edition, Oxford University Press, 2021, pp208 - 243, [Mike Southern]
Mashael A. Alqasem, Claire Fergus, J. Mike Southern, Stephen J. Connon and Vincent P. Kelly, The eukaryotic tRNA-guanine transglycosylase enzyme inserts queuine into tRNA via a sequential bi-bi mechanism, Chemical communications, 56, 2020, p3915 - 3918
S.J. Connon and J.M. Southern, 'Substituted Pyrimidine Derivatives useful in the Treatment of Autoimmune Diseases', Rouse, WO2016050804 (A1), 2020
Mangan D., Mcnabola N., Clark E.H., Bermudez I., Wonnacott S., Southern J.M., Ethyl-for-methyl substitution enhances the subtype specificity of mecamylamine analogues, Organic and Biomolecular Chemistry, 17, (46), 2019, p9892 - 9905
Varghese S, Cotter M, Chevot F, Fergus C, Cunningham C, Mills KH, Connon SJ, Southern JM, Kelly VP. , In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis, Nucleic Acid Research, 45, (4), 2017, p2029 - 2039
David Mangan, Neasa McNabola, Emily H. Clark, Isabel Bermudez, Susan Wonnacott and J. Mike Southern, A new synthesis and preliminary evaluation of some analogues of mecamylamine - a compound with anti-addiction properties, Organic and Biomolecular Chemistry, 14, 2016, p10787 - 10798
Neasa McNabola, Cornelius J. O'Connor, Mark D. Roydhouse, Michael D. Wall, J. Mike Southern, A one-pot synthesis of 3-nitrothiophene and 3-nitro-2-substituted thiophenes, Tetrahedron, 71, (28), 2015, p4598 - 4603
Introduction to Aromatic Chemistry in, editor(s)Chris Rostron Jill Barber , Pharmaceutical Chemistry (Integrated Foundations of Pharmacy), Oxford University Press, 2013, [Mike Southern]
O'Connor, CJ, Roydhouse, MD, Przybyl, AM, Wall, MD, Southern, JM, Facile Synthesis of 3-Nitro-2-substituted Thiophenes, JOURNAL OF ORGANIC CHEMISTRY, 75, (8), 2010, p2534-2538
Southern, J. Mike; O'Neil, Ian A.; Kearns, Peter, A concise synthesis of highly functionalised 4-thiosugar derivatives, Synlett, 14, 2008, p2158 - 2160
Preparation and reactions of iminophosphoranes and their synthetic applications in the aza-Wittig reaction. in, editor(s)P.J. Murphy , Organophosphorus Reagents A Practical Approach in Chemistry, Oxford University Press, 2004, pp151 - [J.Mike Southern and Ian A. O'Neil]
Ian A. O'Neil, J. Mike Southern, J. Chris Woolley and Heather Hobbs, The Synthesis of b-N-Tosylaminohydroxylamines via the Ring Opening of N-Tosylaziridines and Their Use in Reverse-Cope Cyclisations, Tetrahedron Letters, 42, 2001, p8243-
Ian A. O'Neil, Ed Cleator, J. Mike Southern and David J. Tapolczay, The Stereospecific Addition of Hydroxylamines to a,b-Unsaturated Sulfones, Nitriles and Nitro compounds, Tetrahedron Letters, 42, 2001, p8251-
Ian. A. O'Neil, Ed Cleator, J. Mike Southern, Neal Hone, David J. Tapolczay, The Synthesis of Chiral Functionalised Piperidines Using a Reverse-Cope Cyclisation: The Effect of Solvent on Diastereoselectivity, Synlett, 2000, p695-
Ian. A. O'Neil, Ed Cleator, J. Mike Southern, Neal Hone, David J. Tapolczay, The Synthesis of Polyhydroxylated Pyrrolidines Using a Reverse-Cope Cyclisation., Synlett, 2000, p1408-
Ian A. O'Neil and J. Mike Southern, The Synthesis of Functionalised b-Hydroxyhydroxylamines via the Ring Opening of Epoxides and Their Use in Reverse-Cope Cyclisations., Tetrahedron Letters, 39, 1998, p9089-
Ian A. O'Neil, Andrew J. Potter, J. Mike Southern, Alexander Steiner and James V. Barkley, Conformationally Defined Piperazine bis(N-Oxides) Bearing Amino Acid Side Chains., Chemical Communications, 1998, p2511-
Ian A. O'Neil and J. Mike Southern, A New Tin Mediated Pummerer Synthesis of Vinyl Stannanes., Synlett, 1997, p1165-
I. E. Markó, J. M. Southern and H. Adams, Towards the Total Synthesis of Manzamines. Rapid and Efficient Assembly of a Middle Core Model, Tetrahedron Letters, 33, 1992, p4657-
I. E. Markó and J. M. Southern, Triorganothallium Reagents in Organic Chemistry. 1. A Simple, Efficient and Versatile Preparation of Ketones from Acid Chlorides, Journal of Organic Chemistry, 55, 1991, p3368-
I. E. Markó, J. M. Southern and M. L. Kantam, Stoichiometric C-C Bond Formation Using Triorganothallium Reagents., Synlett, 1991, p235-
Non-Peer-Reviewed Publications
J.M. Southern, Commercialisation of research, 1st year medicinal chemistry external lecture series, DIT, 2019
John Michael Southern and David Mangan, 'Derivatives of mecamylamine', Tomkins, 2013, 12 December 2022
Recognition
Representations
Reviewer of Dublin City University's Periodic Programme Review - a review of the BSc in Chemical and Pharmacuetical Sciences.
Awards and Honours
Visiting Professor, Louvain-la-Neuve University, Belgium
Memberships
Chartered Chemist and Member of the Royal Society of Chemistry