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John Southern
Assistant Professor, Chemistry

Publications and Further Research Outputs

Peer-Reviewed Publications

Varghese S, Cotter M, Chevot F, Fergus C, Cunningham C, Mills KH, Connon SJ, Southern JM, Kelly VP. , In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis, Nucleic Acid Research, 45, (4), 2017, p2029 - 2039 Journal Article, 2017 URL

David Mangan, Neasa McNabola, Emily H. Clark, Isabel Bermudez, Susan Wonnacott and J. Mike Southern, A new synthesis and preliminary evaluation of some analogues of mecamylamine - a compound with anti-addiction properties, Organic and Biomolecular Chemistry, 14, 2016, p10787 - 10798 Journal Article, 2016

S.J. Connon and J.M. Southern, 'Substituted Pyrimidine Derivatives useful in the Treatment of Autoimmune Diseases', Rouse, WO2016050804 (A1), 2016 Patent, 2016 URL

Neasa McNabola, Cornelius J. O'Connor, Mark D. Roydhouse, Michael D. Wall, J. Mike Southern, A one-pot synthesis of 3-nitrothiophene and 3-nitro-2-substituted thiophenes, Tetrahedron, 71, (28), 2015, p4598 - 4603 Journal Article, 2015

Introduction to Aromatic Chemistry in, editor(s)Chris Rostron Jill Barber , Pharmaceutical Chemistry (Integrated Foundations of Pharmacy), Oxford University Press, 2013, [Mike Southern] Book Chapter, 2013

Michael Southern and David Mangan, Derivatives of Mecamylamine, 2013, WO2013026852 A2 Patent, 2013

O'Connor, CJ, Roydhouse, MD, Przybyl, AM, Wall, MD, Southern, JM, Facile Synthesis of 3-Nitro-2-substituted Thiophenes, JOURNAL OF ORGANIC CHEMISTRY, 75, (8), 2010, p2534-2538 Journal Article, 2010 DOI

Southern, J. Mike; O'Neil, Ian A.; Kearns, Peter, A concise synthesis of highly functionalised 4-thiosugar derivatives, Synlett, 14, 2008, p2158 - 2160 Journal Article, 2008

Preparation and reactions of iminophosphoranes and their synthetic applications in the aza-Wittig reaction. in, editor(s)P.J. Murphy , Organophosphorus Reagents A Practical Approach in Chemistry, Oxford University Press, 2004, pp151 - [J.Mike Southern and Ian A. O'Neil] Book Chapter, 2004

Ian A. O'Neil, J. Mike Southern, J. Chris Woolley and Heather Hobbs, The Synthesis of b-N-Tosylaminohydroxylamines via the Ring Opening of N-Tosylaziridines and Their Use in Reverse-Cope Cyclisations, Tetrahedron Letters, 42, 2001, p8243- Journal Article, 2001

Ian A. O'Neil, Ed Cleator, J. Mike Southern and David J. Tapolczay, The Stereospecific Addition of Hydroxylamines to a,b-Unsaturated Sulfones, Nitriles and Nitro compounds, Tetrahedron Letters, 42, 2001, p8251- Journal Article, 2001

Ian. A. O'Neil, Ed Cleator, J. Mike Southern, Neal Hone, David J. Tapolczay, The Synthesis of Polyhydroxylated Pyrrolidines Using a Reverse-Cope Cyclisation., Synlett, 2000, p1408- Journal Article, 2000

Ian. A. O'Neil, Ed Cleator, J. Mike Southern, Neal Hone, David J. Tapolczay, The Synthesis of Chiral Functionalised Piperidines Using a Reverse-Cope Cyclisation: The Effect of Solvent on Diastereoselectivity, Synlett, 2000, p695- Journal Article, 2000

Ian A. O'Neil and J. Mike Southern, The Synthesis of Functionalised b-Hydroxyhydroxylamines via the Ring Opening of Epoxides and Their Use in Reverse-Cope Cyclisations., Tetrahedron Letters, 39, 1998, p9089- Journal Article, 1998

Ian A. O'Neil, Andrew J. Potter, J. Mike Southern, Alexander Steiner and James V. Barkley, Conformationally Defined Piperazine bis(N-Oxides) Bearing Amino Acid Side Chains., Chemical Communications, 1998, p2511- Journal Article, 1998

Ian A. O'Neil and J. Mike Southern, A New Tin Mediated Pummerer Synthesis of Vinyl Stannanes., Synlett, 1997, p1165- Journal Article, 1997

I. E. Markó, J. M. Southern and H. Adams, Towards the Total Synthesis of Manzamines. Rapid and Efficient Assembly of a Middle Core Model, Tetrahedron Letters, 33, 1992, p4657- Journal Article, 1992

I. E. Markó, J. M. Southern and M. L. Kantam, Stoichiometric C-C Bond Formation Using Triorganothallium Reagents., Synlett, 1991, p235- Journal Article, 1991

I. E. Markó and J. M. Southern, Triorganothallium Reagents in Organic Chemistry. 1. A Simple, Efficient and Versatile Preparation of Ketones from Acid Chlorides, Journal of Organic Chemistry, 55, 1991, p3368- Journal Article, 1991

Research Expertise


Our overall goal is to exploit synthetic chemistry to probe biological mechanisms in order to understand and provide treatment for disease. Neuronal nicotinic acetylcholine receptors are an extremely exciting set of ion channels that we are targeting by developing sub-type specific ligands. Areas of particular interest to us are: addiction, pain management, Parkinson's disease, Alzheimer's disease, Schizophrenia and anxiety. In another area we employ a slightly different approach. Rather than targeting specific group of receptors the focus is on the preparation of a diverse range of heterosugars, in which the endocyclic oxygen is replaced with another heteroatom e.g. sulphur, nitrogen or selenium. This class of compounds have exciting anti-viral, anti-cancer and anti-bacterial properties and they are also glycosidase inhibitors. The diseases we are targeting via this approach include Hepatitis C, HIV, avian flu, cancer, MRSA, drug resistant TB, diabetes (type 1 and type 2) and obesity. Other areas of interest include chiral alpha-oxy anions, chiral reactions of electron-rich alkenes and remote chirality


Awards and Honours

Visiting Professor, Louvain-la-Neuve University, Belgium Jan-Apr 2006


Chartered Chemist and Member of the Royal Society of Chemistry