Synthetic Chemistry

Porphyrins

A significant amount of work has been performed in the Senge laboratory towards more efficient and robust methods of porphyrin synthesis. Symmetrical porphyrins are widely available through classic condensation routes but demand in recent years for more.......

Cubanes

Considering the geometry of cubane, it is noteworthy that the distance across the cube (the body diagonal) is 2.72 Ň, which is almost equivalent to the distance across a benzene ring, i.e., 2.79 Ň,11,12 which has led to renewed interest....

Structural Chemistry

Proteins containing tetrapyrroles are one of the most common enzyme motifs found in nature. The involvement of the same porphyrin cofactor in quite distinct chemical reactions, biological functions or medical processes indicates the importance of conformational changes in the porphyrin macrocycle to the function of the enzyme.....

Photomedicine

At present, the search for an effective combat of cancer is of great importance due to current treatmentís inability to discriminate between healthy and malignant cells. Alternative approaches such as photodynamic therapy (PDT) came to the forefront of medicinal methodology in the 1980ís at several institutions throughout the world and involve three key components:.....

Biochemistry

Hemeproteins and other tetrapyrrole containing biomolecules form one of the most diverse classes of enzymes present in the natural world. Through recognition of the homologies of the active constituents of the globins....

Materials Chemistry

Porphyrins have outstanding chemical and thermal stability. The macrocyclic structure and chemical reactivity of tetrapyrroles offers architectural flexibility and facilitates the tailoring of chemical, physical and optoelectronic parameters......