•The design, synthesis and biophysical and biochemical study of new dual action agents targeting DNA as intercalators and minor-groove binders with potential as more selective anticancer drugs. Funded by SFI.

•The design, synthesis and biophysical and biochemical study of new chemical probes targeting Guanine-Quadruplexes in oncogenic precursors of Ras, B-Raf, or c-Myc.

•The design, synthesis and biophysical and biochemical study of new Pt complexes of guanidinium based DNA minor-groove binders with potential as anticancer drugs. Funded by SFI.

•The design, synthesis and biochemical study of guanidinium derivatives as tyrosine or threonine/serine kinase inhibitors. These compounds have shown anticancer activity. Funded by the School of Chemistry (TCD) and an Ulysses award.

•The design, synthesis and study of the pharmacological potential of antagonists of alpha2- or alpha2C-adrenoceptors as antidepressants or antipsychotics. These compounds consist in guanidine or 2-aminoimidazoline derivatives connected by a wide range of aromatic or heteroaromatic linkers. Funded by IRC.

•The theoretical study of the nature of Hydrogen bonds and other weak interactions and their implications in chemical and biological systems by means of MO calculations and the analysis of the electron density.